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KMID : 0361120100240020073
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Korean Journal of Transplantation
2010 Volume.24 No. 2 p.73 ~ p.79
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Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation
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Kim Hee-Yeon
Choi Jong-Young
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Abstract
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The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use
of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.
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KEYWORD
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Hepatitis B core antibody positive donor, Prophylaxis, De novo hepatitis B, Liver transplantation
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